During the last 15 years, a significant amount of data related to the crustacean immune system has been generated, mainly led by the advances made in the field of transcriptomic analysis through massive mRNA sequencing technology. In order to shed new light on the genes and metabolic pathways associated with the immune system in shrimp species, we have carried out a meta-analysis using the current literature and the Sequence Read Archive (SRA) database of the National Center for Biotechnology Information (NCBI), which has 1195 published transcriptomic data sets until 31 December 2020, from different tissues and 14 Penaeus species. The transcriptomic analyses published so far have explored the effects of the challenge from viral and bacterial pathogens, as well as abiotic stressors, such as ammonia, temperature, salinity, oxygen deprivation and pH. They have also explored the effect of dietary factors and beneficial microbes (pre- and probiotics) in the immune response. In order to harness the vast amount of information available, multidisciplinary efforts have to generate better genomic tools to overcome the complexity of the genome and to implement the knowledge gained into commercial applications for the improvement of the culture conditions, adaptation of more sustainable feeds and producing strains showing more resilience/tolerance to diseases.

中文翻译：

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虾免疫反应：转录组学观点

在过去的 15 年中，已经产生了大量与甲壳类动物免疫系统相关的数据，主要是通过大规模 mRNA 测序技术在转录组分析领域取得的进步。为了揭示与虾类免疫系统相关的基因和代谢途径，我们利用现有文献和美国国家生物技术信息中心的序列读取档案（SRA）数据库进行了荟萃分析。 NCBI)，截至 2020 年 12 月 31 日，已发布 1195 个转录组数据集，来自不同组织和 14 个对虾物种。迄今为止发表的转录组学分析探讨了来自病毒和细菌病原体的挑战的影响，以及非生物压力源，如氨、温度、盐度、缺氧和 pH 值。他们还探索了饮食因素和有益微生物（益生菌和益生菌）在免疫反应中的作用。为了利用可用的大量信息，多学科的努力必须产生更好的基因组工具来克服基因组的复杂性，并将获得的知识应用到商业应用中，以改善培养条件、适应更可持续的饲料和生产菌株对疾病表现出更强的复原力/耐受性。