An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines were produced with primary or secondary alcohols as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis.

中文翻译：

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三氟甲磺酸钪催化邻氨基苯甲醛和邻氨基苯乙酮与醇的串联转移加氢环化反应

已经实现了有效的Sc催化转移氢化和环化串联反应。该工艺表现出优异的官能团相容性和良好的产率。用伯醇或仲醇作为氢源生产了多种苯并恶嗪。此外，通过放大实验、后期修改和对映选择性合成的初步探索，证明了这一新开发协议的实用性。