Soft enolization conditions are revealed to be markedly better than the typically applied hard enolization protocols for regioselective enoxysilane formation from unsymmetrical 3-substituted cycloalkanones. Five-, six-, and seven-membered cycloalkanones each with 3-methyl, 3-isopropyl, or 3-phenyl substituents were investigated, and in all but one case, regioselectivities were ≥11:1 for enolization away from the substituent. These results are complementary to the regiospecific enoxysilane formation derived from cycloalkenone conjugate addition/enolate silylation.

中文翻译：

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3-取代环烷酮的软烯醇化表现出显着改善的区域控制与硬烯醇化条件

对于从不对称的 3-取代环烷酮形成区域选择性烯氧基硅烷，软烯醇化条件显着优于通常应用的硬烯醇化方案。研究了分别具有 3-甲基、3-异丙基或 3-苯基取代基的五元、六元和七元环烷酮，在除一种情况外的所有情况下，远离取代基的烯醇化区域选择性均≥11:1。这些结果与源自环烯酮共轭加成/烯醇化甲硅烷基化的区域特异性烯氧基硅烷形成互补。