Fusion of extracellular vesicles to cell contributes to many critical biological pathways. Inspired by the natural fusion process, Hang Xing et al. have developed a liposome fusion-based transport strategy, termed as LiFT, that enables incorporating a variety of functional moieties onto both external and internal surfaces of cell membrane with precise orientation control (DOI: 10.1002/anie.202111647). By using LiFT, asymmetric DNA modifications with orthogonal functionalities on each side of cell membrane is demonstrated, realizing applications such as heterotypic cell assembly and intracellular metabolites detection.

中文翻译：

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使用融合球形核酸进行空间控制细胞膜工程的仿生方法

细胞外囊泡与细胞的融合有助于许多关键的生物学途径。受自然融合过程的启发，Hang Xing 等人。已经开发出一种基于脂质体融合的运输策略，称为 LiFT，它能够将各种功能部分结合到细胞膜的外表面和内表面，并具有精确的方向控制（DOI：10.1002/anie.202111647）。通过使用 LiFT，证明了细胞膜两侧具有正交功能的不对称 DNA 修饰，实现了异型细胞组装和细胞内代谢物检测等应用。