COVID-19 pandemic is sweeping across the world. Previous studies have shown that gut microbiota is associated with COVID-19, and operational taxonomic unit (OTU) composed of Blautia genus, Lactobacillus genus, and Ruminococcus genus of Firmicutes is correlated with the severity of COVID-19. Gut microbiota imbalance in colorectal cancer patients may lead to the variation of OTU. Based on the GMrepo database, the gut microbiota of 1374 patients with colorectal neoplasms and 27,329 healthy people was analyzed to investigate the differences in the abundance of microbes between colorectal neoplasms patients and healthy people. Furthermore, We collected feces samples from 12 patients with colorectal cancer and 8 healthy people in Xiangya hospital for metabolomic analysis to investigate the potential mechanisms. Our study showed that the abundance of Blautia and Ruminococcus was significantly increased in colorectal neoplasms, which may increase the severity of COVID-19. The gender and age of patients may affect the severity of COVID-19 by shaping the gut microbiota, but the BMI of patients does not. Our work draws an initial point that gut microbiota imbalance is a risk factor of COVID-19 mortality and gut microbiota may provide a new therapeutic avenue for colorectal cancer patients.

中文翻译：

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结直肠癌患者的肠道菌群失衡，COVID-19 死亡的危险因素

COVID-19 大流行正在席卷全球。先前的研究表明，肠道微生物群与 COVID-19 相关，由厚壁菌属的 Blautia 属、乳杆菌属和瘤胃球菌属组成的操作分类单元 (OTU) 与 COVID-19 的严重程度相关。结直肠癌患者肠道菌群失衡可能导致OTU变异。基于 GMrepo 数据库，分析了 1374 名结直肠肿瘤患者和 27329 名健康人的肠道微生物群，以调查结直肠肿瘤患者和健康人之间微生物丰度的差异。此外，我们还收集了湘雅医院 12 名结直肠癌患者和 8 名健康人的粪便样本进行代谢组学分析，以研究其潜在机制。我们的研究表明，结直肠肿瘤中 Blautia 和瘤胃球菌的丰度显着增加，这可能会增加 COVID-19 的严重程度。患者的性别和年龄可能会通过塑造肠道微生物群来影响 COVID-19 的严重程度，但患者的 BMI 不会。我们的工作得出了一个初步观点，即肠道微生物群失衡是 COVID-19 死亡率的危险因素，肠道微生物群可能为结直肠癌患者提供新的治疗途径。