Objectives: 

To examine the severe ocular complications associated with contact lens wearing in Japan.

Method: 

A questionnaire was sent to 964 ophthalmologist training facilities inquiring for cases of contact lens–associated complications from April 2016 to March 2018. The inclusion criteria were as follows: (1) corrected distance visual acuity ≤0.1 decimal after treatment for 3 months, (2) corneal perforation observed during follow-up, and (3) requiring surgery. A secondary analysis was conducted, inquiring for further information on the type of contact lens, clinical manifestations, and course of treatment.

Results: 

Forty-two patients with infectious keratitis met the inclusion criteria. Eight patients were users of rigid gas-permeable contact lens, and 34 were users of soft contact lens. Microbiological tests were positive in 73.0%. The organisms isolated in microbiological culture were bacteria in 11 patients (Pseudomonas aeruginosa in 9 patients), fungi in 2 patients, and Acanthamoeba in 14 patients. Ten patients were treated with local antibiotics, 11 with a combination of systemic antibiotics, and 21 with a combination of surgical approaches, including 13 with corneal transplantation.

Conclusions: 

The major cause of serious contact lens–associated ocular complications was microbial keratitis, and P. aeruginosa and Acanthamoeba were the major pathogens in Japan.

中文翻译：

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在日本与戴隐形眼镜相关的严重眼部并发症

目标： 

研究日本与佩戴隐形眼镜相关的严重眼部并发症。

方法： 

2016 年 4 月至 2018 年 3 月，向 964 家眼科医生培训机构发送问卷调查隐形眼镜相关并发症病例。纳入标准如下：（1）治疗 3 个月后矫正远视力≤0.1 小数，（2 ) 随访期间观察到角膜穿孔，以及 (3) 需要手术。进行了二次分析，询问有关隐形眼镜类型、临床表现和治疗过程的更多信息。

结果： 

42 名感染性角膜炎患者符合纳入标准。8名患者为硬性透气性隐形眼镜使用者，34名患者为软性隐形眼镜使用者。73.0%的微生物检测呈阳性。微生物培养分离出细菌11例（铜绿假单胞菌9例），真菌2例，棘阿米巴14例。10 名患者接受了局部抗生素治疗，11 名患者接受了全身抗生素联合治疗，21 名患者接受了联合手术治疗，其中 13 名患者接受了角膜移植。

结论： 

严重的隐形眼镜相关眼部并发症的主要原因是微生物角膜炎，而铜绿假单胞菌和棘阿米巴是日本的主要病原体。