Knoevenagel-Cyclization Cascade Reactions of Substituted 5,6-Dihydro-2H-Pyran Derivatives,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Knoevenagel-Cyclization Cascade Reactions of Substituted 5,6-Dihydro-2H-Pyran Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-12-03 , DOI: 10.1002/ejoc.202101277
Sándor Balázs Király _{1,

2} , Attila Bényei ₃ , Erika Lisztes ₄ , Tamás Bíró ₅ , Balázs István Tóth ₄ , Tibor Kurtán ₁

Affiliation

A Knoevenagel-IMHDA and Knoevenagel-[1,5]-hydride shift-cyclization domino reactions took place when reacting o-formylaryl amine or ether containing 5,6-dihydro-2H-pyran derivatives with active methylene reagents. The spiro hetero tricyclic skeletons of the IMHDA products represent a new scaffold and antiproliferative activity with low micromolar IC₅₀ values was identified for two of them.

中文翻译：

取代的 5,6-二氢-2H-吡喃衍生物的 Knoevenagel-环化级联反应

当邻甲酰芳胺或含有 5,6-二氢-2 H-吡喃衍生物的醚与活性亚甲基试剂反应时，会发生 Knoevenagel-IMHDA 和 Knoevenagel-[1,5]-氢化物移位-环化多米诺反应。IMHDA 产品的螺杂三环骨架代表了一种新的支架，其中两个具有低微摩尔 IC ₅₀值的抗增殖活性。

更新日期：2021-12-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11