Coronary atherosclerosis (AS) is characterized by the formation of plaque in the vessel wall. The structural and functional changes of vascular smooth muscle cells (VSMCs) can promote plaque formation and induce plaque instability.

中文翻译：

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miR-222-5p通过靶向RB1促进人血管平滑肌细胞功能障碍

冠状动脉粥样硬化（AS）的特征是在血管壁上形成斑块。血管平滑肌细胞（VSMCs）的结构和功能变化可促进斑块形成并诱导斑块不稳定。