A novel comprehensive assessment system, consisting of a bioassay and chemical analysis, was developed to quickly evaluate the human health risk posed by toxic chemicals discharged due to natural disasters. To analyze samples quickly, a yeast-two-hybrid assay (Y2H) and GC–MS equipped with an automated identification and quantification system (AIQS-GC) were employed for the bioassay and chemical analysis, respectively. Since the analysis of 1000 substances by AIQS could be finished within two days following the Y2H assay for screening, this method would complete the risk assessment within three days. To confirm the applicability of this method in real environmental samples, we examined it using sediments circulated by Typhoon Hagibis. In one sediment sample, a distinctive response was indicated by the Y2H assay, and relatively high DDT concentration was identified by AIQS-GC in the same sediment. Therefore, using the results obtained from this method, a human health risk assessment of DDT was conducted, which indicated that the risk could be ignored. Additionally, the contamination of PAHs and alkanes was suggested as well. In this study, the pollution risk assessment could be completed within three days. Therefore, to our knowledge, this is the first study to demonstrate an assessment system with a rapid combination method for emergencies. Consequently, it is believed that this type of novel system would be needed in the future due to the increasing number of natural disasters predicted worldwide.

开发了一种由生物测定和化学分析组成的新型综合评估系统，以快速评估因自然灾害排放的有毒化学品对人类健康造成的风险。为了快速分析样品，分别采用酵母双杂交法 (Y2H) 和配备自动识别和定量系统 (AIQS-GC) 的 GC-MS 进行生物测定和化学分析。由于 AIQS 对 1000 种物质的分析可在 Y2H 检测筛选后的两天内完成，因此该方法将在三天内完成风险评估。为了确认该方法在实际环境样品中的适用性，我们使用台风海贝斯循环的沉积物对其进行了检查。在一个沉积物样品中，Y2H 测定显示出独特的反应，AIQS-GC 鉴定出同一沉积物中的 DDT 浓度相对较高。因此，利用该方法获得的结果，对 DDT 进行了人体健康风险评估，表明该风险可以忽略不计。此外，还提出了多环芳烃和烷烃的污染。在本研究中，污染风险评估可在三天内完成。因此，据我们所知，这是第一个展示具有快速组合方法的紧急情况评估系统的研究。因此，由于全球预测的自然灾害数量不断增加，相信未来将需要这种新型系统。这表明风险可以忽略不计。此外，还提出了多环芳烃和烷烃的污染。在本研究中，污染风险评估可在三天内完成。因此，据我们所知，这是第一个展示具有快速组合方法的紧急情况评估系统的研究。因此，由于全球预测的自然灾害数量不断增加，相信未来将需要这种新型系统。这表明风险可以忽略不计。此外，还提出了多环芳烃和烷烃的污染。在本研究中，污染风险评估可在三天内完成。因此，据我们所知，这是第一个展示具有快速组合方法的紧急情况评估系统的研究。因此，由于全球预测的自然灾害数量不断增加，相信未来将需要这种新型系统。