We report here an iridium-catalyzed hydroalkynylation of allylic alcohols protected by an oxime group. Catalytic alkynylation occurs exclusively at the distal position of the alkene. This method generates γ-alkynyl alcohol oximes directly from internal alkenes and terminal alkynes. The oxime group can be readily removed to afford a free alcohol, thus providing an indirect route for the catalytic hydroalkynylation of allylic alcohols.

中文翻译：

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肟引导的内部烯烃的铱催化区域选择性氢化炔基化

我们在这里报告了由肟基团保护的烯丙醇的铱催化氢化炔基化。催化炔基化仅发生在烯烃的远端位置。该方法直接从内部烯烃和末端炔烃生成 γ-炔醇肟。肟基可以很容易地去除以提供游离醇，从而为烯丙醇的催化加氢炔基化提供间接途径。