Précis: 

For patients with glaucoma, metabolic syndrome was associated with higher intraocular pressure and greater central corneal thickness. Patients with metabolic syndrome were more likely to have ocular hypertension.

Purpose: 

The purpose of this study was to determine whether glaucomatous optic neuropathy, also known as glaucoma, and ocular hypertension are more likely to occur in patients with metabolic syndrome.

Patients and Methods: 

Patients in Olmsted County, MN, were identified as having metabolic syndrome based on diagnosis codes, laboratory values, and/or medication use to meet 3 or more of the 5 standard criteria for diagnosing metabolic syndrome: systemic hypertension, hyperglycemia, hypertriglyceridemia, reduced high-density lipoprotein cholesterol, and central adiposity defined by increased body mass index. Patients with glaucoma, including primary open angle, low tension, pigment dispersion, and pseudoexfoliation, were identified using diagnostic codes. The charts of patients with glaucoma were individually reviewed to collect visual acuity, intraocular pressure, cup to disc ratio, central corneal thickness, visual field mean deviation, retinal nerve fiber layer thickness, and treatment of intraocular pressure. Patients with ocular hypertension were separately identified and similarly evaluated.

Results: 

For patients with glaucoma, those with metabolic syndrome had higher intraocular pressure and greater central corneal thickness compared with those without metabolic syndrome. After adjustment for central corneal thickness, there was no longer a significant difference in intraocular pressure between groups. Metabolic syndrome was also associated with the diagnosis of ocular hypertension, and although central corneal thickness trended higher in patients with metabolic syndrome, it did not attain statistical significance.

Conclusion: 

In Olmsted County, though metabolic syndrome was associated with ocular hypertension and higher intraocular pressure in patients with glaucoma, the results were likely related to a thicker central corneal in this patient population.

中文翻译：

---

美国中西部人群代谢综合征与青光眼和高眼压的关系

概要： 

对于青光眼患者，代谢综合征与较高的眼内压和较大的中央角膜厚度相关。代谢综合征患者更容易出现高眼压症。

目的： 

本研究的目的是确定代谢综合征患者是否更容易发生青光眼性视神经病变（也称为青光眼）和高眼压症。

患者和方法： 

明尼苏达州奥姆斯特德县的患者根据诊断代码、实验室值和/或药物使用情况被确定为患有代谢综合征，以满足诊断代谢综合征的 5 个标准中的 3 个或更多标准：全身性高血压、高血糖、高甘油三酯血症、高血糖降低-密度脂蛋白胆固醇和由体重指数增加定义的中心性肥胖。使用诊断代码识别青光眼患者，包括原发性开角型、低眼压、色素分散和假性剥脱性青光眼。对青光眼患者进行单独检查，收集视力、眼压、杯盘比、中央角膜厚度、视野平均偏差、视网膜神经纤维层厚度和眼压治疗情况。单独识别高眼压患者并进行类似评估。

结果： 

对于青光眼患者，与无代谢综合征的患者相比，患有代谢综合征的患者眼压更高，中央角膜厚度更大。调整中央角膜厚度后，组间眼压不再存在显着差异。代谢综合征也与高眼压症的诊断相关，尽管代谢综合征患者的中央角膜厚度呈较高趋势，但并未达到统计学显着性。

结论： 

在奥姆斯特德县，尽管代谢综合征与青光眼患者的高眼压和眼内压升高有关，但结果可能与该患者群体的中央角膜较厚有关。