Before the prophylactic use of anti-D antibodies in pregnancy, hemolytic anemia of the newborn was the most common cause of hyperbilirubinemia. Nowadays, given the rarity of hemolytic anemia of the newborn, hepatobiliary abnormalities, perinatal infections, and metabolic disorders have become the most common conditions in the differential diagnosis of neonatal cholestasis. Here, we report 3 instances of cholestatic giant cell hepatitis in 3 infants who had Coombs’ positive hemolysis due to ABO incompatibility in 1, Rh incompatibility in another, and combined ABO and Rh incompatibility in the third. Although rare, cholestatic neonatal giant cell hepatitis associated with hemolysis still needs to be considered in patients with neonatal cholestasis. A marked elevation of aspartate aminotransferase over alanine aminotransferase can be a helpful clue to an early diagnosis.

在妊娠期预防性使用抗 D 抗体之前，新生儿溶血性贫血是高胆红素血症的最常见原因。如今，鉴于新生儿溶血性贫血的罕见性，肝胆异常、围产期感染和代谢紊乱已成为新生儿胆汁淤积鉴别诊断中最常见的情况。在这里，我们报告了 3 例胆汁淤积性巨细胞肝炎的病例，其中 1 例因 ABO 血型不合导致 Coombs 阳性溶血，另一例因 Rh 血型不合，第 3 例为 ABO 和 Rh 血型不合。虽然罕见，但在新生儿胆汁淤积患者中仍需考虑与溶血相关的胆汁淤积性新生儿巨细胞肝炎. 天冬氨酸氨基转移酶明显高于丙氨酸氨基转移酶可能是早期诊断的有用线索。