To evaluate the association of a healthy lifestyle, involving seven low-risk factors mentioned in diabetes management guidelines (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, adequate sleep duration, and appropriate social connection), with all-cause and cause-specific mortality among individuals with type 2 diabetes.

This study included 13,366 participants with baseline type 2 diabetes from the UK Biobank free of cardiovascular disease (CVD) and cancer. Lifestyle information was collected through a baseline questionnaire.

During a median follow-up of 11.7 years, 1,561 deaths were documented, with 625 from cancer, 370 from CVD, 115 from respiratory disease, 81 from digestive disease, and 74 from neurodegenerative disease. In multivariate-adjusted model, each lifestyle factor was significantly associated with all-cause mortality, and hazard ratios associated with the lifestyle score (scoring 6–7 vs. 0–2 unless specified) were 0.42 (95% CI 0.34, 0.52) for all-cause mortality, 0.57 (0.41, 0.80) for cancer mortality, 0.35 (0.22, 0.56) for CVD mortality, 0.26 (0.10, 0.63) for respiratory mortality, and 0.28 (0.14, 0.53) for digestive mortality (scoring 5–7 vs. 0–2). In the population-attributable risk analysis, 29.4% (95% CI 17.9%, 40.9%) of deaths were attributable to a poor lifestyle (scoring 0–5). The association between a healthy lifestyle and all-cause mortality was consistent, irrespective of factors reflecting diabetes severity (diabetes duration, glycemic control, diabetes-related microvascular disease, and diabetes medication).

A healthy lifestyle was associated with a lower risk of all-cause mortality and mortality due to CVD, cancer, respiratory disease, and digestive disease among individuals with type 2 diabetes.

评估健康生活方式的关联，涉及糖尿病管理指南中提到的七个低风险因素（当前不吸烟、适度饮酒、定期体育活动、健康饮食、较少久坐行为、充足睡眠时间和适当的社会联系）， 2 型糖尿病患者的全因和特定原因死亡率。

这项研究包括来自英国生物银行的 13,366 名基线 2 型糖尿病参与者，他们没有心血管疾病 (CVD) 和癌症。通过基线问卷收集生活方式信息。

在 11.7 年的中位随访期间，记录了 1,561 人死亡，其中 625 人死于癌症，370 人死于心血管疾病，115 人死于呼吸系统疾病，81 人死于消化系统疾病，74 人死于神经退行性疾病。在多变量调整模型中，每个生活方式因素与全因死亡率显着相关，与生活方式评分相关的风险比（评分 6-7 对 0-2，除非另有说明）为 0.42（95% CI 0.34, 0.52）全因死亡率，癌症死亡率为 0.57 (0.41, 0.80)，CVD 死亡率为 0.35 (0.22, 0.56)，呼吸系统死亡率为 0.26 (0.10, 0.63)，消化系统死亡率为 0.28 (0.14, 0.53)（评分 5-7与 0-2）。在人群归因风险分析中，29.4% (95% CI 17.9%, 40.9%) 的死亡可归因于不良生活方式（得分 0-5）。

在 2 型糖尿病患者中，健康的生活方式与较低的全因死亡率和因 CVD、癌症、呼吸系统疾病和消化系统疾病导致的死亡风险相关。