Cancer diagnosis and analysis devices based on multimolecular crowding,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cancer diagnosis and analysis devices based on multimolecular crowding
Chemical Communications ( IF 4.3 ) Pub Date : 2021-11-24 , DOI: 10.1039/d1cc05556a
Daisuke Onoshima ₁ , Yoshinobu Baba _{1,

2,

3}

Affiliation

The study of the multimolecular crowding around cancer cells has opened up the possibility of developing new devices for cancer diagnosis and analysis through the measurement of intercellular communication related to cell proliferation and invasive metastasis associated with cancer malignancy. In particular, cells and extracellular vesicles that flow into the bloodstream contain metabolites and secreted products of the cancer microenvironment. These are positioned as targets for the development of new devices for the understanding and application of multimolecular crowding around cancer cells. Examples include the separation analysis of cancer cells in blood for the next generation of less invasive testing techniques, and mapping analysis using Raman scattering to detect cancer cells without staining. Another example is the evaluation of the relationship between exosomes and cancer traits for the exploration of new anti-cancer drugs, and the commercialization of exosome separation devices for ultra-early cancer diagnosis. The development of nanobiodevice engineering, which applies multimolecular crowding to conventional nanobioscience, is expected to contribute to the diagnosis and analysis of various diseases in the future.

中文翻译：

基于多分子拥挤的癌症诊断和分析装置

对癌细胞周围多分子聚集的研究开辟了通过测量与癌症恶性肿瘤相关的细胞增殖和侵袭性转移相关的细胞间通讯来开发用于癌症诊断和分析的新设备的可能性。特别是，流入血流的细胞和细胞外囊泡含有癌症微环境的代谢物和分泌产物。这些被定位为开发新设备的目标，以了解和应用癌细胞周围的多分子拥挤。示例包括血液中癌细胞的分离分析，用于下一代微创检测技术，以及使用拉曼散射进行映射分析以检测癌细胞而不进行染色。另一个例子是评估外泌体与癌症特征之间的关系以探索新的抗癌药物，以及用于超早期癌症诊断的外泌体分离装置的商业化。纳米生物器件工程的发展，将多分子拥挤应用于传统的纳米生物科学，预计将有助于未来各种疾病的诊断和分析。

更新日期：2021-12-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11