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Reconstructable Uterus-Derived Materials for Uterus Recovery toward Efficient Live Births
Advanced Materials ( IF 27.4 ) Pub Date : 2021-12-01 , DOI: 10.1002/adma.202106510 Xiao Yi 1, 2 , Fan Liu 2 , Kunjie Gao 2 , Feng Chen 2 , Yifeng Wang 2 , Huayan Li 2 , Xuefeng Wang 3 , Yi Huang 4 , Huijiao Fu 3 , Weijie Zhou 5 , Jun-Bing Fan 1 , Shutao Wang 6 , Yi Gao 1
Advanced Materials ( IF 27.4 ) Pub Date : 2021-12-01 , DOI: 10.1002/adma.202106510 Xiao Yi 1, 2 , Fan Liu 2 , Kunjie Gao 2 , Feng Chen 2 , Yifeng Wang 2 , Huayan Li 2 , Xuefeng Wang 3 , Yi Huang 4 , Huijiao Fu 3 , Weijie Zhou 5 , Jun-Bing Fan 1 , Shutao Wang 6 , Yi Gao 1
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Uterine factor infertility is increasingly common in modern society and has severely affected human life and health. However, the existing biomaterial scaffold-mediated systems remain limited in efficient uterus recovery, leading to low pregnancy rate and live births. Here, reconstructable uterus-derived materials (RUMs) are demonstrated by combining uterus-derived extracellular matrix and seeded chorionic villi mesenchymal stem cells for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as, liquid RUMs and solid RUMs) and shapes (such as, cuboid, triangular-prism, and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as, accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete recovery after treating with the RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. The study provides a regenerative medicine therapeutics for uterine factor infertility.
中文翻译：
用于子宫恢复以实现高效活产的可重建子宫衍生材料
子宫因素不孕症在现代社会日益普遍，严重影响了人类的生命健康。然而，现有的生物材料支架介导系统在有效子宫恢复方面仍然有限，导致妊娠率和活产率低。在这里，通过结合子宫来源的细胞外基质和接种的绒毛间充质干细胞进行子宫恢复，证明了可重建的子宫来源材料（RUMs），在严重子宫损伤的大鼠中实现了高效的活产。RUM可以根据需要设计成不同的状态（如液体RUM和固体RUM）和形状（如长方体、三棱柱和立方体）。RUMs 可有效防止宫腔粘连，促进子宫内膜再生和肌肉胶原蛋白重建，以及，通过构建物理屏障和分泌细胞因子来加速伤口愈合，从而使子宫有效恢复。受伤的子宫在用 RUM 治疗后几乎完全恢复，并且与正常大鼠相似，可以正常妊娠以支持胎儿发育和活产。该研究为子宫因素不孕症提供了一种再生医学疗法。
更新日期：2021-12-01
中文翻译：
用于子宫恢复以实现高效活产的可重建子宫衍生材料
子宫因素不孕症在现代社会日益普遍，严重影响了人类的生命健康。然而，现有的生物材料支架介导系统在有效子宫恢复方面仍然有限，导致妊娠率和活产率低。在这里，通过结合子宫来源的细胞外基质和接种的绒毛间充质干细胞进行子宫恢复，证明了可重建的子宫来源材料（RUMs），在严重子宫损伤的大鼠中实现了高效的活产。RUM可以根据需要设计成不同的状态（如液体RUM和固体RUM）和形状（如长方体、三棱柱和立方体）。RUMs 可有效防止宫腔粘连，促进子宫内膜再生和肌肉胶原蛋白重建，以及，通过构建物理屏障和分泌细胞因子来加速伤口愈合，从而使子宫有效恢复。受伤的子宫在用 RUM 治疗后几乎完全恢复，并且与正常大鼠相似，可以正常妊娠以支持胎儿发育和活产。该研究为子宫因素不孕症提供了一种再生医学疗法。
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