Response to comment on “Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics”,Science Translational Medicine

当前位置： X-MOL 学术 › Sci. Transl. Med. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Response to comment on “Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics”
Science Translational Medicine ( IF 15.8 ) Pub Date : 2021-12-01 , DOI: 10.1126/scitranslmed.abf4530
Jonas Bovijn _{1,

2} , Kristi Krebs ₃ , Chia-Yen Chen _{4,

5,

6} , Ruth Boxall _{7,

8} , Jenny C Censin _{1,

2} , Teresa Ferreira ₁ , Sara L Pulit _{1,

9,

10} , Craig A Glastonbury ₁ , Samantha Laber _{1,

2} , Iona Y Millwood _{7,

8} , Kuang Lin ₇ , Liming Li ₁₁ , Zhengming Chen ₇ , Lili Milani ₃ , George Davey Smith _{12,

13} , Robin G Walters _{7,

8} , Reedik Mägi ₃ , Benjamin M Neale _{4,

6} , Cecilia M Lindgren _{1,

2,

9,

14} , Michael V Holmes _{1,

7,

8,

14}

Affiliation

Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
Department of Genetics, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands.
Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing 100191, China.
Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Barley House, Oakfield Grove, Bristol BS8 2BN, UK.
National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Triangulation of evidence from clinical trials and human genetics suggests a potential excess risk of cardiovascular disease events arising from therapeutic inhibition of sclerostin.

中文翻译：