Summary: In this issue of Cancer Discovery , Penter and colleagues describe the results of applying the recently described technology of combined assay for transposase-accessible chromatin using sequencing and mitochondrial DNA sequencing in single cells from serial samples from nine patients with chronic lymphocytic leukemia. The naturally occurring barcodes, provided by mitochondrial DNA mutations, allowed tracking of subclones with distinct chromatin accessibility profiles and copy-number alterations demonstrating distinct patterns of tumor evolution under a range of selection pressures. See related article by Penter et al., [p. 3048][1] . [1]: /lookup/volpage/11/3048?iss=12

中文翻译：

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利用 CLL 中 ATAC 克隆进化的线粒体突变

摘要：在本期癌症发现中，Penter 和他的同事描述了应用最近描述的联合检测技术的结果，该技术使用测序和线粒体 DNA 测序对来自 9 名慢性淋巴细胞白血病患者的系列样本的单细胞进行转座酶可接近染色质的组合检测。由线粒体 DNA 突变提供的天然条形码允许跟踪具有不同染色质可及性谱和拷贝数变化的亚克隆，这些变化表明在一系列选择压力下肿瘤进化的不同模式。参见 Penter 等人的相关文章，[p. 3048][1]。[1]：/lookup/volpage/11/3048?iss=12