This study aims to examine interocular differences in the choroidal thickness and vascular density of the choriocapillaris in anisometropic myopes and to further explore the relationship between choroidal blood flow and myopia. The sample comprised 44 participants with anisometropic myopia, aged 9 to 18 years, with normal best-corrected visual acuity. All participants underwent a series of examinations, including spherical equivalent refraction (SER) and axial length (AL), measured by a Lenstar optical biometer and optical coherence tomography angiography (OCTA) scanner. OCT measured the choroidal thickness, vascular density, and flow voids of the choriocapillaris, and a customized algorithm was implemented in MATLAB R2017a with the post-correction of AL. The choroidal thickness was measured at the fovea and 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm nasally, temporally, inferiorly, and superiorly to the fovea. The vascular density and the flow voids of the choriocapillaris were measured at a 0.6-mm-diameter central circle, and the 0.6–2.5 mm diameter circle in the nasal, temporal, inferior, and superior regions. Repeated-measured ANOVAs were used to analyze the interocular differences. Partial correlations with the K value and age adjustments were used to study the relationships between the choroidal thickness, the choriocapillaris vascular density and flow voids, the SER and AL. The choroidal thickness of the more myopic eyes was significantly thinner than less myopic eyes (P ≤ 0.001), and the flow voids in the more myopic eyes were more than less myopic eyes (P = 0.002). There was no significant difference in the vascular density of the choriocapillaris between the more and less myopic eyes (P = 0.525). However, when anisometropia was more than 1.50 D, the vascular density of choriocapillaris in the more myopic eyes was significantly less than the less myopic eyes (P = 0.026). The interocular difference of the choroidal thickness was significantly correlated with the interocular difference in SER and AL in the center, superior, and inferior regions but not in the nasal or temporal regions. The interocular differences of the vascular density and the flow voids of the choriocapillaris were not correlated with the interocular difference of SER and AL. The choroidal thickness is thinner in the more myopic eyes. The flow void is increased, and the vascular density of the choriocapillaris is reduced in the more myopic eyes of children with anisometropia exceeding 1.50 D.

中文翻译：

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近视屈光参差的脉络膜厚度和脉络膜毛细血管密度

本研究旨在检查屈光参差性近视患者脉络膜厚度和脉络膜血管密度的眼间差异，并进一步探讨脉络膜血流与近视之间的关系。该样本包括 44 名患有屈光参差性近视的参与者，年龄在 9 至 18 岁之间，最佳矫正视力正常。所有参与者都接受了一系列检查，包括球面等效折射 (SER) 和轴向长度 (AL)，由 Lenstar 光学生物计和光学相干断层扫描血管造影 (OCTA) 扫描仪测量。OCT 测量脉络膜厚度、血管密度和脉络膜毛细血管的流动空隙，并在 MATLAB R2017a 中实现了定制算法，并对 AL 进行了后校正。在中央凹和 0.5、1.0、1.5、2.0、2.5 和 3 处测量脉络膜厚度。0 毫米的鼻腔、颞侧、下方和上方的中央凹。脉络膜毛细血管的血管密度和流动空隙在直径为 0.6 毫米的中心圆以及鼻、颞、下部和上部区域的 0.6-2.5 毫米直径圆处测量。重复测量的方差分析用于分析眼间差异。使用与 K 值和年龄调整的偏相关来研究脉络膜厚度、脉络膜毛细血管密度和流动空隙、SER 和 AL 之间的关系。近视眼脉络膜厚度明显较近视眼薄（P≤0.001），近视眼血流空隙多于近视眼（P=0.002）。近视眼和近视眼的脉络膜毛细血管密度没有显着差异（P = 0.525）。然而，当屈光参差大于 1.50 D 时，近视眼较近视眼的脉络膜毛细血管密度显着低于近视眼（P = 0.026）。脉络膜厚度的眼间差异与中心区、上区和下区的 SER 和 AL 的眼间差异显着相关，但与鼻或颞区无关。血管密度的眼间差异和脉络膜毛细血管的流动空隙与SER和AL的眼间差异无关。近视眼的脉络膜厚度较薄。流动空隙增加，