With the rapid rise in COVID 19 cases incomparable to the number of vaccinations available, there has been a demand to prioritize the older age groups receiving the vaccine as they have more risk of morbidity and mortality and thus better outcome from vaccination. Some studies showed a lower seroconversion rate in older group patients; thus, we discuss the necessity to reprioritize vaccinations to younger age groups who have better seroconversion rates, but we may face some ethical dilemma that could hinder our hypothesis. Decreased seroconversion rates in adults are attributable to immuno-senescence which involves a decrease in humoral and cellular-mediated immunity with age. Despite this fact, there remains some ethical dilemma that can hinder widespread vaccination of younger generations, the most important of which is the unknown long-term effects of COVID-19 vaccines due their fast-tracking under the pressure of the pandemic. Prioritizing children vaccination against COVID-19 seems an interesting strategy that can help in containing the pandemic. Resolving some ethical dilemma needs to be done before implementing such strategy.

中文翻译：

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我们应该接种更好的血清转化者还是最脆弱的人？COVID-19 疫苗优先级政策的改变游戏规则的见解

随着 COVID 19 病例的迅速增加，与可用的疫苗接种数量相比，人们需要优先考虑接受疫苗的老年人群，因为他们有更高的发病率和死亡率风险，因此接种疫苗的结果更好。一些研究表明，老年组患者的血清转化率较低；因此，我们讨论了对血清转化率更高的年轻群体重新优先接种疫苗的必要性，但我们可能面临一些可能阻碍我们假设的道德困境。成人血清转化率降低可归因于免疫衰老，其涉及体液和细胞介导的免疫随着年龄的增长而降低。尽管如此，仍然存在一些道德困境，可能会阻碍年轻一代的广泛接种，其中最重要的是 COVID-19 疫苗在大流行的压力下快速追踪，因此其未知的长期影响。优先为儿童接种 COVID-19 疫苗似乎是一种有助于遏制大流行的有趣策略。在实施此类策略之前，需要解决一些道德困境。