In this issue of Cancer Cell, Li et al. show that histamine released in allergic reactions and from tumor cells attenuates immunotherapy response. Histamine H₁-receptor (H₁R) signaling induces an M2-like phenotype in tumor-associated macrophages and increases VISTA expression, suppressing CD8⁺ T cell function. Antihistamines reverse these effects and improve the efficacy of immunotherapy.

中文翻译：

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用于癌症免疫治疗的抗组胺药：不仅仅是治疗过敏

在本期《癌细胞》中，Li 等人。研究表明，过敏反应和肿瘤细胞释放的组胺会减弱免疫治疗反应。组胺 H ₁受体 (H ₁ R) 信号传导在肿瘤相关巨噬细胞中诱导 M2 样表型，并增加 VISTA 表达，抑制 CD8 ⁺ T 细胞功能。抗组胺药可逆转这些影响并提高免疫疗法的疗效。