当前位置: X-MOL 学术Nat. Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations
Nature Communications ( IF 14.7 ) Pub Date : 2021-12-02 , DOI: 10.1038/s41467-021-27375-5
L Iskhakova 1, 2, 3 , P Rappel 1, 2 , M Deffains 4, 5 , G Fonar 1 , O Marmor 1, 2 , R Paz 3 , Z Israel 6 , R Eitan 1, 7, 8 , H Bergman 1, 2, 6
Affiliation  

Βeta oscillatory activity (human: 13–35 Hz; primate: 8–24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson’s disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson’s following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks.



中文翻译:


多巴胺音调的调节引起皮质基底节β振荡的频率变化



β 振荡活动(人类:13-35 Hz;灵长类动物:8-24 Hz)在皮层和基底神经节内普遍存在。对帕金森病患者和动物模型的研究表明,β-能量随着多巴胺的消耗而增加。然而,振荡功率、频率和多巴胺音调之间的确切关系仍不清楚。我们记录了健康非人类灵长类动物皮层和基底神经节的神经活动,同时急剧和长期上调和下调多巴胺水平。我们评估了帕金森病患者在多巴胺张力的急性和慢性变化后β振荡的变化。在这里,我们发现猴子和人类的β振荡频率与多巴胺张力密切相关。功率、单个单元和局部场电位 (LFP) 之间的相干性、尖峰 LFP 锁相和相位幅度耦合不受多巴胺水平的系统调节。这些结果表明,β 频率是皮质和基底神经节网络病理振荡的关键特性。

更新日期:2021-12-02
down
wechat
bug