Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex¹. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs² regulate the spatial receptive fields of pyramidal cells³. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing⁴ and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork⁵ to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure.

局部电路结构促进了大脑皮层¹特征选择性的出现。^{在海马体中，特定连接基序2}支持的局部计算是否调节锥体细胞³的空间感受野仍然未知。在这里，我们开发了一种体内电穿孔方法，用于单突触逆行追踪⁴和单细胞分辨率的光遗传学操作，以在导航过程中询问位置细胞与其微电路的动态相互作用。我们在 CA1 中发现了一种局部电路机制，通过这种机制，单个位置单元的空间调整可以传播到功能循环子网⁵它属于哪个。单个神经元中位置场的出现导致其突触前中间神经元子集中逆选择性的发展，并在该位置招募功能耦合的位置细胞。因此，单个 CA1 神经元的空间选择性通过局部电路可塑性得到放大，从而实现有效的多神经元表示，可以在不降低前馈输入结构的情况下灵活地局部缩放环境特征。