Characterization of Chalkophomycin, a Copper(II) Metallophore with an Unprecedented Molecular Architecture,Journal of the American Chemical Society

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Characterization of Chalkophomycin, a Copper(II) Metallophore with an Unprecedented Molecular Architecture
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2021-12-01 , DOI: 10.1021/jacs.1c09311
Bang Gong ₁ , Enhe Bai ₁ , Xueqiong Feng ₁ , Liwei Yi ₁ , Yeji Wang ₁ , Xin Chen ₁ , Xiangcheng Zhu _{1,

2,

3} , Yanwen Duan _{1,

2,

3} , Yong Huang _{1,

3}

Affiliation

Metals play essential roles in life by coordination with small molecules, proteins, and nucleic acids. Although the coordination of copper ions in many proteins and methanobactins is known, the coordination chemistry of Cu(II) in natural products and their biological functions remain underexplored. Herein, we report the discovery of a Cu(II)-binding natural product, chalkophomycin (CHM, 1), from Streptomyces sp. CB00271, featuring an asymmetric square-coordination system of a bidentate diazeniumdiolate and a conjugated 1H-pyrrole 1-oxide-oxazoline. The structure of 1 may inspire the synthesis of Cu(II) chelators against neurodegenerative diseases or Cu(II)-based antitumor therapeutics.

中文翻译：

具有史无前例的分子结构的铜 (II) 金属基团的特性

金属通过与小分子、蛋白质和核酸配位在生命中发挥重要作用。尽管已知许多蛋白质和 methanobactins 中铜离子的配位，但天然产物中 Cu(II) 的配位化学及其生物学功能仍未得到充分探索。在此，我们报告了来自Streptomyces sp。CB00271，具有双齿二醇二氮烯鎓和共轭 1 H-吡咯 1-氧化物-恶唑啉的不对称方形配位系统。1的结构可能会激发针对神经退行性疾病的 Cu(II) 螯合剂或基于 Cu(II) 的抗肿瘤治疗剂的合成。

更新日期：2021-12-15

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