Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses,Angewandte Chemie International Edition

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Fluorescence Imaging of Mitochondrial DNA Base Excision Repair Reveals Dynamics of Oxidative Stress Responses
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-12-01 , DOI: 10.1002/anie.202111829
Yong Woong Jun ₁ , Eddy Albarran ₂ , David L Wilson ₁ , Jun Ding ₂ , Eric T Kool ₁

Affiliation

A light-up fluorescent probe (UBER) that reacts rapidly with apurinic/apyrimidinic (AP) sites visualizes base excision repair (BER) of mitochondrial DNA (mtDNA) in cells. Monitoring of the mtDNA BER process in cells over time illuminated the time lag between the initiation of oxidative stress and the initial step of DNA repair, along with the effect of DNA defensive enzymes, MTH1 and OGG1.

中文翻译：

线粒体 DNA 碱基切除修复的荧光成像揭示了氧化应激反应的动力学

与无嘌呤/无嘧啶 (AP) 位点快速反应的发光荧光探针 (UBER) 可显示细胞中线粒体 DNA (mtDNA) 的碱基切除修复 (BER)。随着时间的推移，对细胞中 mtDNA BER 过程的监测揭示了氧化应激开始和 DNA 修复初始步骤之间的时间滞后，以及 DNA 防御酶 MTH1 和 OGG1 的作用。

更新日期：2022-01-25

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