ABSTRACT

Purpose

To report a case with acute posterior multifocal placoid pigment epitheliopathy (APMPPE)-like presentation following the first dose of BNT162b2 COVID-19 vaccination

Case Report

An otherwise healthy 45-year-old woman presented with a headache and blurred vision in her right eye 7 days after the administration of first dose of mRNA (BNT162b2) COVID-19 vaccine. Fundus examination of the right eye revealed multiple discrete yellow–white placoid lesions at the level of deep retinal layers throughout the posterior pole, while left fundus was unremarkable at that time. Swept source-optical coherence tomography (SS-OCT) showed subretinal fluid together with an appearance of bacillary layer detachment at the right macula. A detailed systemic evaluation was carried out without any positive finding. Two weeks after the initial eye examination, similar multiple placoid lesions were observed in her left eye. Fundus lesions almost totally resolved without any treatment bilaterally 5 weeks after the onset of initial symptoms.

Conclusion

To the best of our knowledge, this is the first report of APMPPE-like presentation described after the BNT162b2 COVID-19 vaccination. Previous COVID-19 vaccination should be kept in mind in the differential diagnosis of APMPPE disease spectrum.

中文翻译：

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首次接种 BNT162B2 COVID-19 疫苗后出现急性多灶性盾状色素上皮病样表现

摘要

目的

报告第一剂 BNT162b2 COVID-19 疫苗接种后出现急性后部多灶性鳞状色素上皮病 (APMPPE) 样表现的病例

案例报告

一名身体健康的 45 岁女性在接种第一剂 mRNA (BNT162b2) COVID-19 疫苗后 7 天出现右眼头痛和视力模糊。右眼眼底检查显示在整个后极的深层视网膜层水平有多个离散的黄白色翼状病变，而当时左眼底并不明显。扫描源光学相干断层扫描 (SS-OCT) 显示视网膜下积液以及右侧黄斑处的细菌层脱离。进行了详细的系统评估，但没有任何积极的发现。初次眼科检查两周后，在她的左眼观察到类似的多发性翼状病变。在初始症状出现后 5 周，双侧眼底病变几乎完全消退，无需任何治疗。

结论

据我们所知，这是 BNT162b2 COVID-19 疫苗接种后描述的 APMPPE 样表现的第一份报告。在 APMPPE 疾病谱的鉴别诊断中应牢记既往接种过 COVID-19 疫苗。