当前位置: X-MOL 学术Nat. Rev. Cancer › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Glycogen condensates drive tumorigenesis by trapping Hippo kinases
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2021-11-30 , DOI: 10.1038/s41568-021-00430-5
Ulrike Harjes 1
Affiliation  

Liu et al. show that glycogen accumulates in pre-malignant liver cells by undergoing liquid–liquid phase separation and, by sequestering Hippo kinases MST1 and MST2, promotes YAP-driven tumorigenesis.

中文翻译:

糖原缩合物通过捕获 Hippo 激酶驱动肿瘤发生

刘等人。表明糖原通过液 - 液相分离在癌变前肝细胞中积累,并通过隔离 Hippo 激酶 MST1 和 MST2 促进 YAP 驱动的肿瘤发生。
更新日期:2021-11-30
down
wechat
bug