The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction. This is a cross-sectional multicenter observational study with prospective recruitment of patients. A total of 798 patients were included in this study. A total of 618 patients (77.4%) had long COVID-19 symptoms. The mean EQI was 2.02 ± 0.99 IC_95% [1.95–2.08]. A total of 397 (49.7%) patients had impaired EQI. Fatigue, chest pain, and neuro-cognitive difficulties were significantly associated with endothelium dysfunction with an EQI <2 after adjustment for age, sex, diabetes, hypertension, dyslipidemia, coronary heart disease, and the severity of acute COVID-19 infection. In multivariate analysis, endothelial dysfunction (EQI <2), female gender, and severe clinical status at acute COVID-19 infection with a need for oxygen supplementation were independent risk factors of long COVID-19 syndrome. Long COVID-19 symptoms, specifically non-respiratory symptoms, are due to persistent endothelial dysfunction. These findings allow for better care of patients with long COVID-19 symptoms.

COVID-19 疾病是一种多系统疾病，部分原因是血管内皮损伤。感染后的持久影响和长期后遗症可能会持续存在，这可能是由于持续的内皮功能障碍所致。我们的研究重点是通过手指热监测和 E4 诊断 Polymath 在一大群长 COVID-19 患者中评估内皮质量指数（EQI），以确定长 covid 19 症状是否与内皮功能障碍有关。这是一项前瞻性招募患者的横断面多中心观察性研究。本研究共纳入 798 名患者。共有 618 名患者 (77.4%) 有长期的 COVID-19 症状。平均 EQI 为 2.02 ± 0.99 IC _95% [1.95——2.08]。共有 397 (49.7%) 名患者有 EQI 受损。在调整年龄、性别、糖尿病、高血压、血脂异常、冠心病和急性 COVID-19 感染的严重程度后，疲劳、胸痛和神经认知困难与内皮功能障碍显着相关，EQI <2。在多变量分析中，内皮功能障碍（EQI <2）、女性和急性 COVID-19 感染时需要吸氧的严重临床状态是长 COVID-19 综合征的独立危险因素。长期的 COVID-19 症状，特别是非呼吸系统症状，是由于持续的内皮功能障碍所致。这些发现可以更好地照顾具有长期 COVID-19 症状的患者。