Atherosclerosis serves as the pathological basis of most cardiovascular and cerebrovascular diseases. C1q tumor necrosis factor–related protein 1 (CTRP1) is a 35-kDa glycoprotein synthesized by various tissues and cells, such as adipose tissue and macrophages. As an adiponectin paralog, CTRP1 signals through adiponectin receptor 1 and participates in a variety of pathophysiological processes. Circulating CTRP1 levels are significantly increased in patients with coronary artery disease. Importantly, CTRP1 was shown to accelerate the development of atherosclerosis by promoting vascular inflammation, macrophage foam cell formation, and endothelial barrier dysfunction. This review focused on recent advances regarding the role of CTRP1 in atherogenesis with an emphasis on its potential as a novel biomarker and a promising therapeutic target for atherosclerosis-related diseases.

动脉粥样硬化是大多数心脑血管疾病的病理基础。C1q 肿瘤坏死因子相关蛋白 1 (CTRP1) 是一种 35 kDa 的糖蛋白，由脂肪组织和巨噬细胞等各种组织和细胞合成。作为脂联素旁系同源物，CTRP1 通过脂联素受体 1 发出信号并参与多种病理生理过程。冠状动脉疾病患者的循环 CTRP1 水平显着升高。重要的是，CTRP1 显示通过促进血管炎症、巨噬细胞泡沫细胞形成和内皮屏障功能障碍来加速动脉粥样硬化的发展。