SIRT1, a member of the sirtuin family of longevity regulators, possesses potent activities preventing vascular ageing. The expression and function of SIRT1 in endothelial cells are downregulated with age, in turn causing early vascular ageing and predisposing various vascular abnormalities. Overexpression of SIRT1 in the vascular endothelium prevents ageing-associated endothelial dysfunction and senescence, thus the development of hypertension and atherosclerosis. Numerous efforts have been directed to increase SIRT1 signaling as a potential strategy for different ageing-associated diseases. However, the complex mechanisms underlying the regulation of SIRT1 have posed a significant challenge towards the design of specific and effective therapeutics. This review aimed to provide a summary on the regulation and function of SIRT1 in the vascular endothelium and to discuss the different approaches targeting this molecule for the prevention and treatment of age-related cardiovascular and cerebrovascular diseases.

中文翻译：

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内皮 SIRT1 作为预防动脉老化的靶点：承诺与挑战。

SIRT1 是长寿调节因子 Sirtuin 家族的成员，具有有效预防血管老化的活性。SIRT1在内皮细胞中的表达和功能随着年龄的增长而下调，进而导致血管早期老化并诱发各种血管异常。SIRT1 在血管内皮中的过度表达可防止与衰老相关的内皮功能障碍和衰老，从而防止高血压和动脉粥样硬化的发生。人们已经做出了许多努力来增加 SIRT1 信号传导，作为治疗不同衰老相关疾病的潜在策略。然而，SIRT1 调节背后的复杂机制对设计特异性和有效的治疗方法提出了重大挑战。本综述旨在总结SIRT1在血管内皮细胞中的调控和功能，并讨论针对该分子预防和治疗年龄相关心脑血管疾病的不同方法。