PURPOSE The purpose of the study is to determine the microbiological etiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University, Egypt. METHODS Prospective, nonrandomized, observational clinical series of cases, including 150 patients with mean age 30 (range 12 to 85 years), 90 patients (60%) were males and 60 (40%) were females, clinically diagnosed as infective corneal ulcer, attending the Ophthalmology Department-Faculty of Medicine. Minia University, Minia, Egypt. From December 2018 to December 2020. Detailed history taking and all clinical findings were collected. Corneal scrapings were obtained from patients and subjected to staining and culture for bacterial and fungal pathogens; Bacterial and fungal growth were identified by standard laboratory procedures. RESULTS Corneal trauma by a vegetative matter was the commonest risk factor associated with infective keratitis in 92 cases (61.3%). Smear and culture was positive in 83 cases (58.4%) of 142 corneal scrapings obtained, of which 60 cases were fungal (72.3%), 21 cases were bacterial (25.3%) and two cases were mixed bacterial and fungal (2.4%), Aspergillus species was the commonest fungal species isolated in fungal keratitis. One hundred forty-two cases (94.67%) healed completely with scar. Only six cases (4%) required evisceration due to aggressive presentation from the start and keratoplasty was performed for two cases (1.33%). CONCLUSIONS Fungal keratitis was the commonest type in cases attending to our department. Adequate diagnosis, management and follow-up helped in achieving high successful curative outcomes. CLINICAL TRIAL NUMBER Clinical Trials.gov ID: NCT04894630. Time of registration 1 December 2018.

中文翻译：

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细菌性和真菌性角膜炎的流行病学、临床特征和治疗结果。

目的 本研究的目的是确定埃及米尼亚大学眼科感染性角膜炎的微生物学病因、流行病学因素、临床特征和治疗结果。方法前瞻性、非随机、观察性临床系列病例，包括150例患者，平均年龄30岁（12～85岁），男性90例（60%），女性60例（40%），临床诊断为感染性角膜溃疡，就读于眼科 - 医学院。米尼亚大学，米尼亚，埃及。从 2018 年 12 月到 2020 年 12 月。收集了详细的病史采集和所有临床发现。角膜刮片取自患者，对细菌和真菌病原体进行染色和培养；通过标准实验室程序确定细菌和真菌的生长。结果 92例（61.3%）植物性角膜损伤是感染性角膜炎最常见的危险因素。142例角膜刮片中涂片培养阳性83例（58.4%），其中真菌60例（72.3%），细菌21例（25.3%），细菌和真菌混合2例（2.4%），曲霉属是真菌性角膜炎中最常见的真菌种类。142例（94.67%）瘢痕完全愈合。仅 6 例 (4%) 因从一开始就表现出侵略性而需要摘除内脏，其中 2 例 (1.33%) 进行了角膜移植术。结论真菌性角膜炎是我科就诊病例中最常见的类型。充分的诊断，管理和跟进有助于实现高度成功的治疗结果。临床试验编号 Clinical Trials.gov ID：NCT04894630。注册时间 2018 年 12 月 1 日。