Histopathological studies have revealed key processes of atherosclerotic plaque thrombosis. However, the diversity and complexity of lesion types highlight the need for improved sub- phenotyping. We hypothesized that unbiased clustering of plaques based on gene expression results in an alternative categorization of late-stage atherosclerotic lesions.

中文翻译：

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基于转录组学的晚期动脉粥样硬化斑块聚类识别具有与临床表现相关的不同潜在生物学的斑块亚组

组织病理学研究揭示了动脉粥样硬化斑块血栓形成的关键过程。然而，病变类型的多样性和复杂性突出了改进亚表型的必要性。我们假设基于基因表达的斑块的无偏聚类导致晚期动脉粥样硬化病变的替代分类。