The present review aims to collect the published literature pertaining the recognition of isobaric compounds (isomers or stereoisomers) using the features of tandem mass spectrometry (MS) experiments without any chromatographic separation or chemical modification (derivatization or isotopic enrichment) of the analytes. MS/MS methods possess high selectivity, wide dynamic range and high throughput capabilities. Generally, tandem MS has limited capability for distinguishing isomers that fragment similarly. However, some MS/MS methods have been developed and positively applied to isomers discrimination. Among the literature on this topic, the applications that fit on the review subject can be summarized as follow: (1) chiral discrimination by the kinetic method, (2) the use energy-resolved tandem mass spectra and the survival yield (SY) representation, (3) the kinetics evaluation of the ion-molecule interaction and (4) the postprocessing mathematical algorithm to resolve the isomers in MS/MS signal.

中文翻译：

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用于识别异构化合物混合物的串联质谱方法

本综述旨在收集有关使用串联质谱 (MS) 实验的特征识别同量异位化合物（异构体或立体异构体）的已发表文献，而无需对分析物进行任何色谱分离或化学修饰（衍生化或同位素富集）。MS/MS 方法具有高选择性、宽动态范围和高通量能力。通常，串联 MS 区分类似碎片的异构体的能力有限。然而，一些 MS/MS 方法已经开发出来并积极应用于异构体鉴别。在有关该主题的文献中，适合综述主题的应用可归纳如下：（1）通过动力学方法进行手性鉴别，