Process intensification is the best approach to improve processing as there is immense need for sustainable, efficient and cost-effective processes for many chemical and biological industries. Ultrasound is one of the approaches that offer promise because of its safety, environment friendly and energy saving abilities. Ultrasound results in acoustic cavitation leading to several physical and chemical effects including acoustic streaming and enhanced mixing based on turbulence that can increase the desired yield in different bioprocesses. The present work deals with intensification of fermentative production of streptomycin using low frequency ultrasound. The focus is on understanding the effect of processing conditions such as time of ultrasound treatment, power dissipation and duty cycle so as to maximize the yield of streptomycin. The optimized ultrasound (US) parameters for the streptomycin fermentation were established as 4 min US treatment, 40 kHz frequency, 200 W power and 100% duty cycle. It was observed that in the case of fermentation, the US treatment increased the production by around 31% as compared to the control operation in the absence of ultrasound. Overall, the process intensification benefits of using ultrasound have been clearly established for the studied bioprocess as fermentation of streptomycin.

过程强化是改进加工的最佳方法，因为许多化学和生物行业都迫切需要可持续、高效和具有成本效益的过程。超声波是一种很有前景的方法，因为它具有安全、环保和节能的能力。超声波导致声学空化，导致多种物理和化学效应，包括声流和基于湍流的增强混合，可以增加不同生物过程中的所需产量。目前的工作涉及使用低频超声强化链霉素的发酵生产。重点是了解超声处理时间、功率耗散和占空比等处理条件的影响，以最大限度地提高链霉素的产量。链霉素发酵的优化超声 (US) 参数被确定为 4 分钟 US 处理、40 kHz 频率、200 W 功率和 100% 占空比。据观察，在发酵的情况下，与没有超声波的对照操作相比，US 处理使产量增加了约 31%。总体而言，对于所研究的生物过程，如链霉素发酵，已经明确确立了使用超声波的过程强化优势。