Background

To assess potential associations between the ankle-brachial blood pressure index (ABI) and ocular disorders.

Methods

In the population-based cross-sectional Russian Ural Eye and Medical Study including 5,899 (80.5%) out of 7328 eligible participants aged 40+ years, the participants underwent a series of ocular and medical examinations including measurement of ABI.

Results

Blood pressure measurements of both arms and ankles were available for 3187 (54.0%) individuals. The mean ABI was 1.26 ± 0.19 (median:1.20; range: 0.61, 2.20). In multivariate analysis, a higher ABI was associated with younger age (P < 0.001; non-standardized regression coefficient B: −0.001; 95% confidence interval (CI): −0.002, −0.001), female sex (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04), lower body mass index (P < 0.001; B: −0.004; 95% CI: −0.006, −0.003), lower waist-to-hip ratio (P = 0.01; B: −0.10; 95% CI: −0.17, −0.02), lower glucose serum concentration (P = 0.008; B: −0.005; 95% CI: −0.009, −0.001), lower prevalence of arterial hypertension (P < 0.001; B: −0.14; 95% CI: −0.16, −0.12), higher mean systolic blood pressure (P < 0.001; B: 0.003; 95% CI: 0.002, 0.003), and higher prevalence of any alcohol consumption (P < 0.001; B: 0.03; 95% CI: 0.02, 0.04). In that multivariate model, prevalence of glaucoma (P = 0.67) as a whole, open-angle glaucoma (P = 0.86) and angle-closure glaucoma (P = 0.54), stage of glaucomatous optic neuropathy (P = 0.57), prevalence of age-related macular degeneration (P = 0.88), prevalence and stage of diabetic retinopathy (P = 0.30, and P = 0.29, respectively), nuclear cataract (P = 0.32, and P = 0.41, resp.), cortical cataract (P = 0.33, and P = 0.92, resp.), subcapsular cataract (P = 0.74 and P = 0.60, resp.), and pseudoexfoliation (P = 0.44 and P = 0.47, resp.), intraocular pressure (P = 0.52), axial length (P = 0.20), and peripapillary retinal nerve fibre layer thickness (P = 0.55) were not significantly associated with the ABI.

Conclusions

In this ethnically mixed population from Russia, none of the major ocular diseases was associated with ABI suggesting that subclinical atherosclerosis is not markedly associated with the aetiology of these ocular disorders.

中文翻译：

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俄罗斯人群的踝臂指数和眼部疾病

背景

评估踝臂血压指数 (ABI) 与眼部疾病之间的潜在关联。

方法

在基于人群的俄罗斯乌拉尔眼科和医学横断面研究中，7328 名 40 岁以上符合条件的参与者中有 5,899 人 (80.5%) 接受了一系列眼科和医学检查，包括 ABI 测量。

结果

3187 (54.0%) 人的双臂和脚踝血压测量可用。平均 ABI 为 1.26 ± 0.19（中位数：1.20；范围：0.61、2.20）。在多变量分析中，较高的 ABI 与较年轻（P  < 0.001；非标准化回归系数 B：-0.001；95% 置信区间 (CI)：-0.002，-0.001）、女性（P  < 0.001；B ：0.03；95% CI：0.02，0.04），较低的体重指数（P  < 0.001；B：-0.004；95% CI：-0.006，-0.003），较低的腰臀比（P  = 0.01；B ：-0.10；95% CI：-0.17，-0.02），较低的葡萄糖血清浓度（P  = 0.008；B：-0.005；95% CI：-0.009，-0.001），较低的动脉高血压患病率（P < 0.001；B：-0.14；95% CI：-0.16，-0.12），平均收缩压较高（P  < 0.001；B：0.003；95% CI：0.002，0.003），任何酒精消费的流行率较高（P  < 0.001；B：0.03； 95% 置信区间：0.02、0.04）。在该多变量模型中，青光眼总体患病率 ( P  = 0.67)、开角型青光眼 ( P  = 0.86) 和闭角型青光眼 ( P  = 0.54)、青光眼性视神经病变阶段 ( P  = 0.57)、年龄相关性黄斑变性 ( P  = 0.88)、糖尿病性视网膜病变的患病率和分期 (分别为P  = 0.30 和P  = 0.29)、核性白内障 ( P  = 0.32 和P  = 0.41，分别）、皮质性白内障（分别为P  = 0.33 和P  = 0.92）、囊下白内障（分别为P  = 0.74 和P  = 0.60）和假性剥脱（分别为P  = 0.44 和P  = 0.47， resp.）、眼压（P  = 0.52）、眼轴长度（P  = 0.20）和视盘周围视网膜神经纤维层厚度（P  = 0.55）与 ABI 无显着相关性。

结论

在这个来自俄罗斯的种族混合人群中，没有一种主要的眼部疾病与 ABI 相关，这表明亚临床动脉粥样硬化与这些眼部疾病的病因学没有显着相关性。