George F. Vande Woude Jr., a pioneer in retrovirology and molecular oncology, a tremendous scientific mentor, and an all-around versatile, exuberant human being, passed away on April 13, 2021. George was one of the first scientists to consider the molecular basis of cancer. He determined that long-terminal repeat segments linked to oncogenes could transform mammalian cells, and his laboratory defined the cellular functions of oncogenes c-MOS and MET. He was also one of the first to investigate the role of protein kinases in cell cycle regulation and to document p53 function in genomic stability, leading to novel therapies for many forms of cancer. Besides discoveries archived in more than 300 publications amassed over George’s 45+-year career, he was an outstanding scientific administrator, able to balance the need for organization and scientific integrity with the urgency required to enable innovative research. This attribute may in fact have contributed as much to George’s legacy as his laboratory’s laudatory achievements, his skillful leadership and direct, intuitive communications facilitated the work of many researchers and laboratories to broadly advance scientific discovery.

中文翻译：

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庆祝乔治·范德·沃德 (George Vande Woude) 的生平 [回顾]

小乔治·范德·沃德 (George F. Vande Woude) 是逆转录病毒学和分子肿瘤学的先驱、伟大的科学导师，也是一个多才多艺、精力充沛的人，于 2021 年 4 月 13 日去世。乔治是首批考虑癌症的分子基础。他确定与癌基因相关的长末端重复片段可以转化哺乳动物细胞，他的实验室定义了癌基因c-MOS和MET 的细胞功能。他也是最早研究蛋白激酶在细胞周期调节中的作用并记录 p53 在基因组稳定性中的作用的人之一，从而为多种形式的癌症带来了新的疗法。除了在乔治 45 多年的职业生涯中积累的 300 多份出版物中的发现之外，他还是一位杰出的科学管理者，能够平衡对组织和科学完整性的需求与实现创新研究所需的紧迫性。事实上，这一属性对乔治的遗产的贡献可能与他的实验室的美誉成就一样大，他娴熟的领导能力和直接、直观的沟通促进了许多研究人员和实验室的工作，以广泛推进科学发现。