Titanium oxynitride (TiOxNy) coatings increase the bio- and hemocompatibility of stainless steel and Co-Cr vascular stents, possibly by directly releasing NO. Herein, to examine the applicability of this approach to nitinol (NiTi) devices, we coated NiTi samples with TiOx or TiOxNy by reactive magnetron sputtering using different reaction gas compositions and bias voltages. One side of the samples was preliminarily abraded, while the other remained in its original state. Samples morphology, composition and structure were studied by atomic force microscopy (AFM), X-ray diffraction (XRD) and field emission scanning electron microscopy (FE SEM). We investigated how various types of TiOx and TiOxNy coatings interact with EA.hy926 endothelial cells. None of the tested samples exhibited cytotoxicity, and an N2:O2 ratio of 3:1 regardless of the bias voltage was found to be optimal for NO production and cell adhesion, spreading, and viability, which was ascribed to a cumulative positive effect of the composition and nanoroughness of TiOxNy coatings formed under these conditions. Thus, the deposition of TiOxNy coatings was concluded to be a promising strategy of increasing the biocompatibility of NiTi stents.

氮氧化钛 (TiOxNy) 涂层提高了不锈钢和 Co-Cr 血管支架的生物相容性和血液相容性，可能是通过直接释放 NO。在此，为了检查这种方法对镍钛诺 (NiTi) 器件的适用性，我们通过反应性磁控溅射使用不同的反应气体成分和偏置电压在 NiTi 样品上涂覆了 TiOx 或 TiOxNy。样品的一侧被初步磨损，而另一侧保持其原始状态。通过原子力显微镜 (AFM)、X 射线衍射 (XRD) 和场发射扫描电子显微镜 (FE SEM) 研究样品的形貌、成分和结构。我们研究了各种类型的 TiOx 和 TiOxNy 涂层如何与 EA.hy926 内皮细胞相互作用。测试样品均未表现出细胞毒性，且 N2:O2 比率为 3: 发现无论偏置电压如何，对于 NO 产生和细胞粘附、扩散和生存能力，1 的结果都是最佳的，这归因于在这些条件下形成的 TiOxNy 涂层的组成和纳米粗糙度的累积积极影响。因此，TiOxNy 涂层的沉积被认为是提高 NiTi 支架生物相容性的有前途的策略。