As COVID-19 vaccination is being undertaken all over the world, its side effects are materializing slowly. One such emerging side effect is acute graft rejection in corneal transplant (CT) cases post COVID-19 vaccination. We report a case of left eye (LE) repeat penetrating keratoplasty presenting with diminished vision in LE within 2 days of COVID-19 vaccination (ChAdOx1 nCoV-19 Corona Virus Vaccine Recombinant, COVISHIELD™). The patient was diagnosed with acute graft rejection post vaccination and was treated with topical and systemic immunosuppression therapy with successful outcome in terms improvement of visual acuity and corneal graft clarity. Timely presentation, diagnosis, and management may help to survive acute rejection episodes post vaccination.

中文翻译：

---

COVID-19 疫苗接种后高危角膜移植中的急性移植排斥：病例报告。

随着全世界都在进行 COVID-19 疫苗接种，其副作用正在缓慢显现。一种新出现的副作用是 COVID-19 疫苗接种后角膜移植 (CT) 病例中的急性移植物排斥反应。我们报告了一例左眼 (LE) 重复穿透性角膜移植术，在接种 COVID-19（ChAdOx1 nCoV-19 Corona Virus Vaccine Recombinant，COVISHIELD™）后 2 天内出现 LE 视力下降。该患者在接种疫苗后被诊断为急性移植物排斥反应，并接受了局部和全身免疫抑制治疗，在改善视力和角膜移植物清晰度方面取得了成功。及时就诊、诊断和管理可能有助于在疫苗接种后的急性排斥反应中存活下来。