The aim of this work is the study of antibacterial photodynamic inactivation (APDI) of Escherichia coli (on the example of a model E. coli K12 TG1), the influence of the charge of photosensitizer (PS) molecules on the efficiency of binding with these Gram-negative bacteria. The results obtained confirm that PSs based on polycationic phthalocyanines and synthetic bacteriochlorins provide effective photodynamic inactivation of E. coli, much higher than monocationic methylene blue and electro-neutral bacteriochlorin derivative. The efficiency of APDI, assessed by the intensity of bioluminescence of model E. coli K12 TG1 bacteria, correlates with the charge of PS molecules and the efficiency of electrostatic binding of PS to bacterial cells.

这项工作的目的是研究大肠杆菌的抗菌光动力灭活 (APDI) （以大肠杆菌K12 TG1模型为例），光敏剂 (PS) 分子的电荷对与这些结合效率的影响革兰氏阴性菌。获得的结果证实，基于聚阳离子酞菁和合成菌绿素的 PS 可提供有效的光动力灭活大肠杆菌，远高于单阳离子亚甲蓝和电中性菌绿素衍生物。APDI 的效率，通过模型大肠杆菌的生物发光强度评估 K12 TG1 细菌，与 PS 分子的电荷和 PS 与细菌细胞的静电结合效率相关。