PURPOSE

Although diagnosing vitreoretinal lymphoma (VRL) can be challenging, early detection is critical for visual prognosis. We analyzed the spectrum of optical coherence tomography (OCT) findings in patients with biopsy-proven VRL and correlate these features with clinical parameters.

DESIGN

This retrospective cross-sectional study was a multicenter chart review from 13 retina, uveitis, and ocular oncology clinics worldwide from 2008 to 2019. We included patients with a diagnosis of biopsy-proven VRL imaged with OCT at presentation. Ocular information, systemic information, and multimodal retinal imaging findings were collected and studied. The main outcome measure was the characteristics of VRL on OCT.

RESULTS

A total of 182 eyes of 115 patients (63 women, mean age 65 years) were included in this study. The disease was bilateral in 81 patients (70%), and mean baseline visual acuity was 0.2 ± 0.89 logMAR (Snellen equivalent, 20/32). At baseline, 38 patients (33%) presented with isolated ocular involvement, 54 (45%) with associated central nervous system involvement, and 11 (10%) with other systemic lymphomatous involvement; an additional 12 patients (10%) presented with central nervous system and other systemic involvement. On OCT, tumor infiltration was identified in various retinal layers, including lesions in the subretinal pigment epithelium compartment (91% of eyes), the subretinal compartment (43% of eyes), and the intraretinal compartment (7% of eyes). OCT analysis of eyes with VRL identified 3 main regions of retinal infiltration. Subretinal pigment epithelium location, with or without subretinal infiltration, was the most common pattern of involvement and isolated intraretinal infiltration was the least.

中文翻译：

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经活检证实的玻璃体视网膜淋巴瘤的高级 OCT 分析

目的

尽管诊断玻璃体视网膜淋巴瘤 (VRL) 可能具有挑战性，但早期发现对于视力预后至关重要。我们分析了经活检证实的 VRL 患者的光学相干断层扫描 (OCT) 结果的范围，并将这些特征与临床参数相关联。

设计

这项回顾性横断面研究是对 2008 年至 2019 年全球 13 家视网膜、葡萄膜炎和眼肿瘤诊所的多中心图表审查。我们纳入了在就诊时用 OCT 成像诊断为经活检证实的 VRL 的患者。收集和研究眼部信息、系统信息和多模态视网膜成像结果。主要结果指标是 OCT 上 VRL 的特征。

结果

本研究共纳入 115 名患者（63 名女性，平均年龄 65 岁）的 182 只眼。81 名患者 (70%) 患有双侧疾病，平均基线视力为 0.2 ± 0.89 logMAR（Snellen 等效视力，20/32）。在基线时，38 名患者 (33%) 表现为孤立的眼部受累，54 名 (45%) 伴有相关的中枢神经系统受累，11 名 (10%) 伴有其他全身性淋巴瘤受累；另有 12 名患者 (10%) 出现中枢神经系统和其他全身受累。在 OCT 上，在不同的视网膜层发现了肿瘤浸润，包括视网膜下色素上皮室（91% 的眼睛）、视网膜下室（43% 的眼睛）和视网膜内室（7% 的眼睛）的病变。对具有 VRL 的眼睛进行的 OCT 分析确定了 3 个主要的视网膜浸润区域。