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Does synchronous early head and neck cancer with esophageal cancer need treatment after preoperative chemotherapy?
General Thoracic and Cardiovascular Surgery ( IF 1.1 ) Pub Date : 2021-11-27 , DOI: 10.1007/s11748-021-01744-9
Kohei Kanamori 1, 2 , Daisuke Kurita 1 , Yuki Hirano 1 , Koshiro Ishiyama 1 , Junya Oguma 1 , Kenkichi Masutomi 2, 3 , Hiroyuki Daiko 1
Affiliation  

Objective

Treatment options for patients with resectable thoracic esophageal squamous cell cancer (ESCC) and synchronous head and neck cancer (HNC) are unclear. Little has been reported about the effects of chemotherapy on early HNC. The aim of this study was to investigate the treatment outcomes of resectable thoracic ESCC with synchronous early HNC.

Methods

We retrospectively reviewed 37 patients undergoing esophagectomy for thoracic ESCC with synchronous early HNC from January 2008 to December 2018.

Results

Among 37 patients who had synchronous early HNC, 27 patients received preoperative therapy for ESCC before HNC treatment, and 16 of 27 patients achieved a complete response for HNC by preoperative chemotherapy. Fifteen of 16 patients did not receive additional treatment, and regional recurrence of HNC was not observed. In one other case, an oral excision was performed, but no cancer cell remnants were found pathologically. No significant difference in overall survival and disease-free survival was observed between 15 patients with follow-up and 22 patients with surgery or radiation.

Conclusion

Our results indicate that early HNC with comorbid ESCC could be followed up without additional treatment if preoperative chemotherapy is successful.



中文翻译:

同步早期头颈癌合并食管癌需要术前化疗后治疗吗?

客观的

可切除胸段食管鳞状细胞癌 (ESCC) 和同步头颈癌 (HNC) 患者的治疗方案尚不清楚。关于化疗对早期 HNC 影响的报道很少。本研究的目的是探讨可切除的胸段 ESCC 与同步早期 HNC 的治疗结果。

方法

我们回顾性分析了 2008 年 1 月至 2018 年 12 月期间接受食管切除术的 37 例胸段 ESCC 合并早期 HNC 患者。

结果

37例同步早期HNC患者中,27例患者在HNC治疗前接受了ESCC术前治疗,27例患者中有16例通过术前化疗达到HNC完全缓解。16 例患者中有 15 例未接受额外治疗,未观察到 HNC 局部复发。在另一种情况下,进行了口腔切除,但病理上未发现癌细胞残留。15 例随访患者和 22 例手术或放疗患者的总生存期和无病生存期无显着差异。

结论

我们的结果表明,如果术前化疗成功,早期 HNC 合并 ESCC 无需额外治疗即可随访。

更新日期:2021-11-27
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