The goal of the biotransformation process is to develop structural changes and generate new chemical compounds, which can occur naturally in mammalian and microbial organisms, such as filamentous fungi, and represent a tool to achieve enhanced bioactive compounds. Cunninghamella spp. is among the fungal models most widely used in biotransformation processes at phase I and II reactions, mimicking the metabolism of drugs and xenobiotics in mammals and generating new molecules based on substances of natural and synthetic origin. Therefore, the goal of this review is to highlight the studies involving the biotransformation of Cunninghamella species between January 2015 and March 2021, in addition to updating existing studies to identify the similarities between the human metabolite and Cunninghamella patterns of active compounds, with related advantages and challenges, and providing new tools for further studies in this scope.

中文翻译：

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坎宁安菌属生物转化的最新进展。

生物转化过程的目标是发展结构变化并产生新的化合物，这些化合物可以在哺乳动物和微生物有机体（如丝状真菌）中自然发生，并代表实现增强生物活性化合物的工具。坎宁安菌属 是在 I 期和 II 期反应的生物转化过程中最广泛使用的真菌模型之一，它模仿哺乳动物中药物和外源性物质的代谢，并基于天然和合成来源的物质生成新分子。因此，本综述的目的是强调 2015 年 1 月至 2021 年 3 月期间涉及杉木属物种生物转化的研究，此外还更新现有研究以确定人类代谢物与活性化合物的杉木属模式之间的相似性，