Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway,Computational and Structural Biotechnology Journal

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Structure-based identification of a new IAP-targeting compound that induces cancer cell death inducing NF-κB pathway
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-11-26 , DOI: 10.1016/j.csbj.2021.11.034
Federica Cossu ₁ , Simone Camelliti _{1,

2} , Daniele Lecis ₂ , Luca Sorrentino _{1,

3} , Maria Teresa Majorini ₂ , Mario Milani ₁ , Eloise Mastrangelo ₁

Affiliation

Inhibitors of apoptosis proteins (IAPs) are validated onco-targets, as their overexpression correlates with cancer onset, progression, diffusion and chemoresistance. IAPs regulate cell death survival pathways, inflammation, and immunity. Targeting IAPs, by impairing their protein–protein interaction surfaces, can affect events occurring at different stages of cancer development.

中文翻译：

基于结构的新型 IAP 靶向化合物的鉴定，该化合物可诱导癌细胞死亡（诱导 NF-κB 通路）

凋亡蛋白抑制剂 (IAP) 是经过验证的肿瘤靶标，因为它们的过度表达与癌症的发病、进展、扩散和化疗耐药相关。 IAP 调节细胞死亡存活途径、炎症和免疫。通过损害 IAP 的蛋白质-蛋白质相互作用表面，靶向 IAP 可以影响癌症发展不同阶段发生的事件。

更新日期：2021-11-26

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