Background: Oxidative damage has been found in various types of hair loss. As a polyphenolic phytoalexin, resveratrol (RSV) is known as an antioxidant, anti-inflammatory and anti-apoptotic agent.
Objective: Thus, we aim to examine the effects of RSV on hair growth.
Methods: In vivo C57BL/6 mice were used to evaluate the effects of RSV on hair cycle, hair length, skin thickness, hair follicle diameter, hair cycle score and the percentage of hair cycle stage. Then hair shaft length and hair cycle were evaluated by human hair follicles (HFs) ex vivo. The proliferative activities of human dermal papilla cells (hDPCs) cultured in vitro with RSV were assessed using RTCA. The ability of RSV to protect hDPCs against H₂O₂-induced oxidative damage is examined by a ROS assay kit.
Results: Topical application of RSV significantly promoted hair growth and stimulated the transition of hair cycle from telogen into the anagen phase on shaved C57BL/6 mice. Ex vivo experiments showed that RSV increased the hair shaft length of HFs and delayed the entry into catagen. In vitro experiments indicated that RSV proliferated hDPCs and prevented hDPCs from oxidative damage caused by H₂O₂.
Conclusion: RSV can promote hair growth and may be a potential candidate for the treatment of hair loss.



中文翻译：

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白藜芦醇对小鼠、人毛囊和真皮乳头细胞的毛发生长促进作用

背景：在各种类型的脱发中都发现了氧化损伤。作为一种多酚类植物抗毒素，白藜芦醇 (RSV) 被称为抗氧化剂、抗炎剂和抗凋亡剂。
目的：因此，我们旨在检查 RSV 对头发生长的影响。
方法：采用体内C57BL/6小鼠，评价RSV对毛发周期、毛发长度、皮肤厚度、毛囊直径、毛发周期评分和毛发周期分期百分比的影响。然后通过离体人毛囊 (HF) 评估毛干长度和头发周期。使用 RTCA 评估体外培养的 RSV 人真皮乳头细胞 (hDPC) 的增殖活性。RSV 保护 hDPC 免受 H ₂ O _{2影响的能力}诱导的氧化损伤通过 ROS 检测试剂盒进行检查。
结果： RSV 的局部应用显着促进了剃毛 C57BL/6 小鼠的毛发生长并刺激毛发周期从休止期过渡到生长期。体外实验表明 RSV 增加了 HF 的毛干长度并延迟了进入退行期。体外实验表明RSV增殖hDPCs并防止hDPCs受到H ₂ O ₂引起的氧化损伤。
结论： RSV可促进毛发生长，可能是治疗脱发的潜在候选者。