The first N-ligand assisted Pd catalyzed asymmetric synthesis of 3-arylsuccinimides as novel antifungal leads,Organic Chemistry Frontiers

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The first N-ligand assisted Pd catalyzed asymmetric synthesis of 3-arylsuccinimides as novel antifungal leads
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2021-11-22 , DOI: 10.1039/d1qo01510a
Jixing Lai ₁ , Juan Yang ₁ , Chen Yang ₁ , René Csuk ₂ , Baoan Song ₁ , Shengkun Li ₁

Affiliation

The first palladium/chiral nitrogenous ligand-catalyzed enantioselective addition of aryl boronic acids to various maleimides was reported. This protocol features mild conditions combined with good functional group tolerance. The resultant 3-arylsuccinimides were shown to be novel chiral antifungal leads and inspired the discovery of novel ligands to address the challenging issues of this transformation.

中文翻译：

第一个 N-配体辅助 Pd 催化不对称合成 3-芳基琥珀酰亚胺作为新型抗真菌先导物

报道了第一个钯/手性含氮配体催化的芳基硼酸对各种马来酰亚胺的对映选择性加成。该协议具有温和的条件和良好的官能团耐受性。所得的 3-芳基琥珀酰亚胺被证明是新型手性抗真菌先导物，并激发了新配体的发现，以解决这种转变的挑战性问题。

更新日期：2021-12-01

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