Currently image-based optical measurement methods are the main approaches for detecting and tracking the movements of droplets or particles in microfluidic devices. However, the massive image data throughput and high computational consumption of image processing have become challenges to achieve real-time and long-term monitoring. Here a single-pixel tracking system is proposed to monitor the microfluidic device on the basis of single-pixel imaging and microscope technology without image reconstruction. The experimental results of tracking droplet in microfluidic device demonstrate that the proposed system have unique potential advantages in dynamic tracking for microfluidic devices. The data throughput of the proposed method is 1/792 of image-based methods and can reach an equivalent frame rate of 312.5 Hz with a low computational consumption of 89.3 μs per frame. The proposed image-free tracking method provides a welcomed boost to the further development of microfluidic device monitoring and indicates a potential way to real-time and long-term monitoring without image processing.

目前基于图像的光学测量方法是检测和跟踪微流体装置中液滴或颗粒运动的主要方法。然而，海量的图像数据吞吐量和图像处理的高计算消耗成为实现实时和长期监控的挑战。这里提出了一种基于单像素成像和显微镜技术的单像素跟踪系统来监测微流体装置，无需图像重建。在微流控装置中跟踪液滴的实验结果表明，所提出的系统在微流控装置的动态跟踪方面具有独特的潜在优势。该方法的数据吞吐量是基于图像的方法的 1/792，可以达到 312 的等效帧率。5 Hz，每帧 89.3 μs 的低计算消耗。所提出的无图像跟踪方法为微流体设备监测的进一步发展提供了可喜的推动力，并表明了一种无需图像处理的实时和长期监测的潜在方法。