A one-pot protocol for constructing 1,4-difunctionalized quinoline/pyridine derivatives via the reaction of N-heteroaromatics, alkyl halides, and active methylene/methyl compounds was developed. The transformation involves dearomative functionalization of an in situ-activated N-heteroaromatic to construct new C−N and C=C bonds. This reaction has a broad substrate scope and functional group tolerance.

中文翻译：

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用于构建亚乙烯基杂环的氮杂芳烃的位点选择性 1,4-双官能化

开发了一种通过 N-杂芳烃、卤代烷和活性亚甲基/甲基化合物的反应构建 1,4-双官能化喹啉/吡啶衍生物的一锅法。该转化涉及原位活化的 N-杂芳烃的去芳烃官能化，以构建新的 C-N 和 C=C 键。该反应具有广泛的底物范围和官能团耐受性。