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Manganese(III)-Promoted Double Carbonylation of Anilines Toward α-Ketoamides Synthesis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2021-11-25 , DOI: 10.1002/adsc.202101233
Xiao-Feng Wu 1 , bo chen 2 , Chang-Sheng Kuai 2 , Jian-Xing Xu 2
Affiliation  

Employing anilines as nucleophiles in double carbonylation is a longstanding challenge. In this communication, a Mn(III)-promoted double carbonylation of alkylborates or Hantzsch esters with anilines toward the synthesis of α-ketoamides has been developed. By using easily available potassium alkyltrifluoroborates or Hantzsch esters as the starting material, and cheap and non-toxic Mn(OAc)3 ⋅ 2H2O as the promotor, a broad range of alkyl α-ketoamide derivatives were synthesized in moderate to good yields with excellent selectivity.

中文翻译:

锰 (III) 促进苯胺双羰基化合成 α-酮酰胺

在双羰基化中使用苯胺作为亲核试剂是一个长期的挑战。在本次交流中,已经开发了一种 Mn(III) 促进的烷基硼酸盐或 Hantzsch 酯与苯胺的双羰基化,用于合成 α-酮酰胺。通过使用容易获得的烷基三氟硼酸钾或 Hantzsch 酯作为起始材料,并以廉价且无毒的 Mn(OAc) 3  · 2H 2 O 作为促进剂,以中等至良好的收率合成了范围广泛的烷基α-酮酰胺衍生物。优良的选择性。
更新日期:2021-11-25
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