Age-related macular degeneration (AMD) is a leading cause of severe, irreversible vision impairment in developed countries, and its prevalence is rising all over the world, increasing sharply with age. AMD represents an acquired degeneration of the retina that causes significant central visual impairment through a combination of noneovascular and neovascular derangement. The main risk factors for the development of advanced AMD are increasing age, genetic factors, and cigarette smoking; however, the exact pathophysiology of AMD is yet relatively poorly understood. In recent years, the gut microbiota has been intensively studied and linked to several pathologic processes, including ocular diseases. In this sense, the aim of this review is to gather published evidence about the relationship between gut microbiota and AMD.

年龄相关性黄斑变性 (AMD) 是发达国家严重、不可逆视力障碍的主要原因，其患病率在世界范围内呈上升趋势，并随着年龄的增长而急剧增加。AMD 代表视网膜的获得性变性，通过非新生血管和新生血管紊乱的组合导致显着的中心视力障碍。发展为晚期 AMD 的主要危险因素是年龄增长、遗传因素和吸烟；然而，AMD 的确切病理生理学仍知之甚少。近年来，人们对肠道微生物群进行了深入研究，并将其与包括眼部疾病在内的多种病理过程联系起来。从这个意义上说，本综述的目的是收集已发表的关于肠道微生物群与 AMD 之间关系的证据。