OBJECTIVE To describe the clinical profile and microbiology trends in patients undergoing therapeutic keratoplasty at a multi-tier ophthalmology hospital network in India. METHODS This cross-sectional hospital-based study included 3147 eyes undergoing therapeutic keratoplasty between Jan 2016 and Dec 2020 (5 years period) as cases. The demographic data, clinical profile and microbiological analysis were collected using an electronic medical record system. RESULTS Of a total of 13,625 eyes with microbial keratitis(non-viral), 3147 (23.1%) underwent therapeutic keratoplasty during the study duration. Majority of patients were males (68.35%), from a rural geography (49.89%) and in 51-60 years age bracket (23.74%). The mean age of the patients was 50.54 ± 15.83 years. Two-thirds of patients were from lower socio-economic strata (66.63%) with an agrarian background (36.51%). Of the 3,147 eyes, fungus (51.8%) was the most common indication of therapeutic keratoplasty followed by bacteria (16.87%) and parasite (1.27%). No organisms could be identified in about a third (29.33%) of the cases. Between 2016 and 2020, the trend of therapeutic keratoplasties for fungal infections steadily grew (39.9% vs 45.49%) while the bacterial infections showed a steady decline (23.15% vs 11.81%). CONCLUSIONS Medical cure rate was seen in majority of those with microbial keratitis, and 23.1% eventually required management with therapeutic keratoplasty. Fungal keratitis was the most common indication for therapeutic keratoplasty. Male gender, rural setting, low socio-economic background and agricultural occupation are common risk factors for patients undergoing therapeutic keratoplasty in India.

中文翻译：

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印度三级护理眼科中心网络中治疗性角膜移植术的临床概况和微生物学趋势。

目的 描述印度多层眼科医院网络中接受治疗性角膜移植术患者的临床概况和微生物学趋势。方法 这项基于医院的横断面研究包括 2016 年 1 月至 2020 年 12 月（5 年期间）期间接受治疗性角膜移植术的 3147 只眼睛作为病例。使用电子病历系统收集人口统计数据、临床概况和微生物分析。结果 在总共 13,625 只患有微生物角膜炎（非病毒性）的眼睛中，3147 只（23.1%）在研究期间接受了治疗性角膜移植术。大多数患者是男性（68.35%），来自农村地区（49.89%）和 51-60 岁年龄段（23.74%）。患者的平均年龄为 50.54 ± 15.83 岁。三分之二的患者来自较低的社会经济阶层（66. 63%) 具有农业背景 (36.51%)。在 3,147 只眼睛中，真菌（51.8%）是治疗性角膜移植术最常见的适应症，其次是细菌（16.87%）和寄生虫（1.27%）。在大约三分之一（29.33%）的病例中没有发现任何生物。2016年至2020年间，真菌感染的治疗性角膜移植术趋势稳步增长（39.9%对45.49%），而细菌感染则呈稳步下降趋势（23.15%对11.81%）。结论 大多数微生物角膜炎患者的内科治愈率均达到，23.1% 的患者最终需要接受治疗性角膜移植术治疗。真菌性角膜炎是治疗性角膜移植术最常见的适应症。男性、农村环境、低社会经济背景和农业职业是印度接受治疗性角膜移植术患者的常见风险因素。