PURPOSE Vasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc. METHODS In this cross-sectional study, 40 patients with SSc and 23 age-matched controls were included. The following parameters were measured using SS-OCT: mean and sectoral retinal nerve fibre layer (RNFL) thickness, macular ganglion cell layer complex (GCC) thickness and ONH morphology. Nailfold capillaroscopy (NFC) and digital blood flow measurements using laser Doppler imaging (LDI) were performed in all subjects. RESULTS Patients with SSc showed a thinner temporal RNFL than the controls (69.23 ± 11.74 versus 83.35 ± 20.19 µm, p = 0.001). The other parameters were similar between the two groups. In SSc patients, there was an inverse correlation between the disease duration and the average, superior and inferior RNFL thickness and the GCC thickness and between Raynaud's phenomenon duration and the average RNFL and GCC thickness (p < 0.05). NFC and LDI measurements did not show correlations with OCT parameters. CONCLUSION A thinner temporal RNFL and the correlation between Raynaud's phenomenon and disease duration and structural abnormalities on OCT suggest the presence of early ganglion cell damage in patients with SSc. Although mild, these findings indicate the need to monitor ocular abnormalities in SSc.

中文翻译：

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在系统性硬化症患者中使用扫描源光学相干断层扫描与青光眼相关的结构异常。

目的 血管痉挛代表系统性硬化症 (SSc) 的早期事件。眼部血管痉挛可诱发视神经乳头（ONH）损伤，并参与了青光眼，尤其是正常眼压性青光眼（NTG）的发病机制。我们旨在使用扫描源光学相干断层扫描 (SS-OCT) 研究与 NTG 相关的结构异常的存在，并将 OCT 参数与 SSc 患者的临床、毛细血管镜检查和数字血流测量值相关联。方法 在这项横断面研究中，纳入了 40 名 SSc 患者和 23 名年龄匹配的对照。使用 SS-OCT 测量以下参数：平均和扇形视网膜神经纤维层 (RNFL) 厚度、黄斑神经节细胞层复合体 (GCC) 厚度和 ONH 形态。在所有受试者中进行了甲襞毛细血管镜检查 (NFC) 和使用激光多普勒成像 (LDI) 的数字血流测量。结果 SSc 患者的颞叶 RNFL 比对照组更薄（69.23 ± 11.74 vs 83.35 ± 20.19 µm，p = 0.001）。两组的其他参数相似。在 SSc 患者中，疾病持续时间与平均、上、下 RNFL 厚度和 GCC 厚度之间以及雷诺现象持续时间与平均 RNFL 和 GCC 厚度之间存在负相关（p < 0.05）。NFC 和 LDI 测量未显示与 OCT 参数的相关性。结论 较薄的时间 RNFL 与雷诺之间的相关性' s 现象和病程以及 OCT 上的结构异常表明 SSc 患者存在早期神经节细胞损伤。虽然轻微，但这些发现表明需要监测 SSc 的眼部异常。